Managing Common Side Effects of Ozempic® and Wegovy®

Ozempic® and Wegovy®—both containing semaglutide—are powerful GLP-1 receptor agonists used for type 2 diabetes and medical weight management. While these medications are highly effective for improving blood sugar control, reducing appetite, and supporting sustainable weight loss, many users experience side effects, especially in the first few weeks of treatment.

Here’s a breakdown of the most common side effects of semaglutide and evidence-based strategies to manage them effectively.

✅ 1. Nausea

One of the most common side effects of GLP-1 medications like Ozempic and Wegovy is nausea, particularly during dose escalation.

Why it happens: Semaglutide delays gastric emptying, helping you feel full longer—but this can cause stomach discomfort initially.

How to Manage Nausea:

Start Low, Go Slow: Always follow your healthcare provider’s gradual dose escalation plan.

Eat Smaller, Frequent Meals: Large meals can worsen nausea. Stick to light, frequent snacks.

Avoid Greasy or Spicy Foods: These often intensify stomach upset.

Stay Hydrated: Sip ginger tea, peppermint tea, or water throughout the day.

Take Medication With Food: If nausea is severe, contact our team at WeightSimple.com to explore prescription anti-nausea options.

✅ 2. Constipation

Semaglutide slows intestinal movement, which can lead to constipation.

How to Manage Constipation:

Increase Fiber Intake: Add fruits, veggies, legumes, and whole grains to your meals.

Hydrate Well: Water supports healthy digestion and fiber absorption.

Get Active: Regular walking or light exercise promotes bowel motility.

Try Fiber Supplements: Products like psyllium husk or stool softeners (e.g., docusate sodium) can help.

✅ 3. Headaches

Headaches can occur as a result of dehydration, fluctuations in blood sugar, or even changes in diet.

How to Manage Headaches:

Drink Enough Water: Aim for 8+ cups/day—more if active or in warm environments.

Use OTC Pain Relief (if needed): Acetaminophen or ibuprofen may help, but always use under guidance.

Practice Stress Relief: Try breathing exercises, meditation, and prioritize restful sleep.

✅ 4. Fatigue

Feeling tired is another possible side effect, especially in the early stages of treatment.

How to Manage Fatigue:

Eat Balanced Meals:Ensure your body is fuelled with protein, healthy fats, and complex carbs.

Establish a Sleep Routine:Aim for 7–9 hours/night and maintain consistent sleep/wake times.

Stay Physically Active:Light exercise can increase your energy over time.

✅ 🚨 When to Contact a Healthcare Provider

While most side effects are mild and temporary, you should seek medical attention if you experience:

Persistent or severe nausea, vomiting, or diarrhea

Severe abdominal pain (especially if radiating to the back—could indicate pancreatitis)

Signs of an allergic reaction: rash, swelling, or difficulty breathing

Rapid heart rate, dizziness, or fainting

🩺 Clinical Support at WeightSimple.com

At WeightSimple.com, we specialize in using GLP-1 medications like Ozempic and Wegovy safely and effectively as part of our virtual medical weight loss program. Our team of doctors, nurse practitioners, and registered dietitians monitors every patient closely for dose titration, side effect management, and long-term success.

📞 Have questions about your weightsimple.com care plans? Contact us anytime by visiting https://www.weightsimple.com/get-started.

📌 Final Thoughts

Starting Ozempic or Wegovy can be a life-changing decision for your health, but it's important to understand how to manage side effects as your body adjusts. Most symptoms improve with time and the right strategies. Staying in touch with your care team ensures a smoother, safer journey toward your health goals.